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January 6, 1962

Human Genetics: Principles and Methods

JAMA. 1962;179(1):102. doi:10.1001/jama.1962.03050010104032

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This is not a textbook in the conventional sense; it deals exclusively with certain principles and methods in human genetics. There is no mention of the genetics of corn, mice, or fruit flies, no descriptions of hereditary diseases, and no description of cytological techniques.

One distinctive feature of human genetics is that it involves both the classical Mendelian genetics and the modern population genetics. Thus, these constitute the first 2 chapters of Dr. Li's book, entitled "Family Laws and the Population Laws." These are followed by 4 chapters on methodology: viz., estimation of gene frequencies in general and those of blood groups in particular. The special methods of determining segregation ratio in human families are explained with diagrams. The method of studying and interpreting of the association between genetic trait and disease is discussed. The pitfalls of pooling heterogeneous data are dramatically illustrated.

Probably the least understood subject in this

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