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Original Contribution
April 10, 1967

Paternal Immunoglobulin Abnormalities in Congenital Hypogammaglobulinemia

Author Affiliations

From the Department of Medicine and the Clinical Research Center, Kansas University Medical Center, Kansas City.

JAMA. 1967;200(2):105-110. doi:10.1001/jama.1967.03120150061008

The serums of relatives of male children with hypogammaglobulinemia were examined for the content of immunoglobulins. In three instances the concentration of IgM was low in the fathers and in two of these cases the same abnormality was also found in the paternal grandfathers. In a fourth family the father had generalized hypogammaglobulinemia and the paternal grandmother had a low concentration of IgM. Abnormalities were not found in the mothers.

These observations suggest a role for paternal genetic factors in the inheritance of some forms of hypogammaglobulinemia. Although the number of cases studied to date is small, it is possible that these abnormalities may identify the male carrier of this disorder and facilitate genetic counseling.