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Preliminary Communication
April 10, 1967

Hyperbaric Oxygen Therapy in Mice Injected With Tetanus Toxin

JAMA. 1967;200(2):129-131. doi:10.1001/jama.1967.03120150085014

The any highly effective, predictable form of treatment for patients victimized by tetanus has challenged the medical profession for centuries. Progress in therapy has been painfully slow, so that morbidity and mortality have not been altered appreciably in the past several decades. Thus, tetanus retains its unsavory position as one of man's most dread disease. Bytchenko,1 in a recent report to the World Health Organization, stated that during the ten-year period of 1951 through 1960 there were more than 1 million victims of this disease; more importantly, approximately 500,000 of them died.

Renewed interest in the therapeutic use of hyperbaric oxygen in various diseases in recent years has led to trials of this treatment in patients afflicted with anaerobic infections. Boerema (written communication, Sept 30, 1964), though encouraged by observations on its use in 50 patients with gas gangrene, did not see any startling benefits in 13 patients with

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