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To the Editor:—
I read with interest the editorial entitled "Immune Reactions of Platelets" (JAMA178:255 [Oct. 14] 1961). There is little question that platelet agglutination by serum is a nonspecific phenomenon rather than a specific and reliable indication of iso- or autoimmunization to platelets, at least in the great majority of cases (Stefanini, M., and Silverberg, J. H.: Amer J Clin Path21:1030 [Nov.] 1951). More precise and reliable techniques (precipitation and complement fixation) have indicated that the demonstration of platelet agglutinins in the serum of patients with chronic idiopathic thrombocytopenic purpura has the primary value of directing the attention of the investigator to possible immune mechanisms, which can be demonstrated more specifically by the other techniques (Stefanini, M., and Mele, R. H.: Acta Haemat20:195 [July-Oct.] 1958).It would be of great value if any single criterion or laboratory test could demonstrate reliably the potential
Stefanini M. Immune Reactions of Platelets. JAMA. 1962;179(2):180. doi:10.1001/jama.1962.03050020074017
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