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Clinical Notes
April 10, 1967

Reiter's Syndrome: Treatment With Methotrexate

Author Affiliations

From the Department of Dermatology, Charity Hospital of Louisiana at New Orleans (Drs. Farber and Forshner); the Civilian Institute Division, Air Force Institute of Technology (Capt Farber); Louisiana State University School of Medicine (Drs. Farber and O'Quinn); and Tulane University School of Medicine (Dr. Forshner), New Orleans. Capt Farber is now on active duty with the Air Force and is stationed in Vietnam.

JAMA. 1967;200(2):171-173. doi:10.1001/jama.1967.03120150127035

REITER'S SYNDROME or the oculourethral synovial syndrome is usually characterized by the presence of arthritis, conjunctivitis, and urethritis. Other fairly common manifestations include diarrhea and the presence of skin lesions. Myocarditis, pericarditis, and neuritis have been less frequently reported.1-4

The disease occurs most commonly in young white men and follows a variable course marked by spontaneous remissions and exacerbations. In some patients the disease process may be mild, clearing completely within three or four months. Other patients, however, may be acutely and severely ill. Permanent joint damage may occur and the disease may run a protracted course.

The etiology of this disease has not been well defined. Although Neisseria gonorrhoeae, the pleuropneumonia-like organisms, and other microorganisms have been implicated in the etiology, close search has failed to establish any organism as the cause of this disease. Grimble5 was able, in patients with Reiter's syndrome and rheumatoid spondylitis, to