THE CURRENT INTEREST in regional cancer chemotherapy has been stimulated by several factors: (1) Although many cancer chemotherapeutic compounds have been developed and are currently undergoing clinical investigation in patients with far-advanced cancer, most reports have shown that the systemic administration of these agents has not resulted in significant practical value in the management of most common forms of cancer. (2) Many common forms of cancer, although beyond conventional therapy, remain localized throughout their evolution and produce symptoms and death from the locally confined, yet uncontrolled, growths. Regional cancer chemotherapy has been developed in an effort to increase the regional effect of antitumor agents in patients with advanced cancer whose tumors are within the distribution of accessible arteries.
A method of regional administration of anticancer drugs has been reported which consists of the continuous arterial administration of an antimetabolite through catheters inserted into the major vessels supplying a tumor-bearing area.
Sullivan RD, McPeak CJ. A Favorable Response in Tongue Cancer to Arterial Infusion Chemotherapy. JAMA. 1962;179(4):293–295. doi:10.1001/jama.1962.03050040047013b
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