Twenty cases of primary lymphoma of the gastrointestinal tract are presented. These lesions, similar to epithelial tumors, disclosed their presence most commonly by pain, nausea, vomiting, melena, palpable mass, and anemia. Survival after operative recovery ranged from 5 weeks to 15 years. Among patients with tumors involving the terminal ileum and colon the average survival was 8 months. Patients with tumors proximal to the ileum survived considerably longer. Malignant lymphomas may arise in unicentric or multicentric foci. When they arise in a single focus they may metastasize and behave like carcinoma. Unlike carcinoma, however, they tend to be more malignant in the lower and less malignant in the upper gastrointestinal tract. Exact diagnosis of primary lymphomas of the gastrointestinal tract prior to surgical exploration or biopsy is difficult. Roentgenologic methods of study remain most helpful.
Parkhurst GF, MacMillan SF. Longevity in Lymphomas of the Lower Intestinal Tract. JAMA. 1962;179(5):351–354. doi:10.1001/jama.1962.03050050041007
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