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February 3, 1962

Contributions to Medicine by Research in Pharmacology: Some Aspects of Dosage

Author Affiliations

New York City

JAMA. 1962;179(5):355-360. doi:10.1001/jama.1962.03050050045008

THROUGH the study of drugs during the last half century and especially the last 25 years, pharmacology has proffered something more substantial than merely drugs. Actually thousands of drug substances have appeared in the pharmacologie arena; most have commanded only fleeting attention, some have atttracted more compelling interest for academic or clinical reason, but all, simply because they have been the objects of pharmacologie research, have been the means by which have arisen those principal concerns that uniquely constitute modern pharmacology. These essential matters of pharmacology have lasting qualities which are being continuously refined and sharpened through research. It is these enduring and evolving principles that furnish the measuring devices which permit us to make rational judgments and optimal application of drug materials.

Rather than discuss these principles, I have elected to review some aspects of one of these, namely, the dose-response relationship, to call to attention its meaning, its