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February 3, 1962


JAMA. 1962;179(5):368-369. doi:10.1001/jama.1962.03050050058010

The structural changes in the kidneys of rats that occur as a response to the alterations in electrolyte balance which accompany potassium deficiency have been found to be localized to the collecting tubules.1 These changes consisted of a general hyperplasia of the tubular epithelial cells in the outer zone of the medulla, a specific hyperplasia of the intercalated cells in the same area, and the development of droplets in cells of the papillary portion of the collecting system. There was also a defect in ability to concentrate urine. MacKay and Oliver2 observed that massive phosphate loading produced extensive changes in the kidney and that these changes consisted of necrosis and calcification of the terminal segment of the proximal convolutions.

Extensive changes have been observed recently in the cortex of kidneys of rats acutely depleted of chloride. These changes in the experiments of Holiday and co-workers3 consisted of