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February 10, 1962

PROLONGED VENOARTERIAL PERFUSION IN ACUTE PULMONARY EMBOLISM

JAMA. 1962;179(6):452-453. doi:10.1001/jama.1962.03050060062011

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Abstract

Certain successful application for venoarterial perfusion are outlined by Reed in the current issue of The Journal ( p. 424). The equipment must be simple, easily assembled, and readily available. The subject must have a potentially reversible illness. Reed induced acute pulmonary embolism in anesthetized dogs by injection of mineral oil into the left jugular vein. A plastic catheter was placed in the left femoral artery, the right femoral artery, and the jugular vein. Connections were made between the jugular vein, femoral artery, and a latex rubber ventricle in a sigma motor pumphead. Heparin was given intravenously. An electronically-cycled mechanical ventilator was used in certain animals to provide controlled oxygen ventilation of the lungs.

Of a group of 45 animals, 26 suffered an acute response to the mineral oil embolus. Death followed the acute symptoms within a few seconds unless measures were taken to reverse the severe hypotension, right heart distension,

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