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February 10, 1962

Dosage of Aminopterin

Author Affiliations

Lederle Laboratories, Pearl River, N.Y.

JAMA. 1962;179(6):470. doi:10.1001/jama.1962.03050060080020

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To the Editor:—  It was called to our attention (JAMA178:46 [Oct. 21] 1961) that a misstatement had been made in a correction. In this notation Dr. Kushner commented on an article, Treatment of Reticulosis (JAMA175:84 [Jan. 14] 1961), wherein the dosage of aminopterin was incorrectly stated. We concur that this dosage is incorrect. However, Dr. Kushner is in error in stating that aminopterin has been taken off the market. Aminopterin is available for the treatment of acute leukemia in children, and we have no present intention of removing it from the market.Dr. Kushner, however, commits a misstatement which has caused considerable confusion in that he states "It so happens that amethopterin...." Dr. Kushner is referring to methotrexate. Methotrexate was formally known as amethopterin, but this name was discontinued because it is readily confused with aminopterin. Methotrexate has one, and only one, name. Methrotrexate is the

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