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The long-awaited second edition of Kabat and Mayer's book has now appeared. It has actually been rewritten by Kabat, with a long and highly-detailed chapter on complement and complement fixation (and one on the Kjeldahl nitrogen method) by Mayer. Since the first edition appeared in 1948, the science of immunochemistry, as a specialized approach to immunology, has progressed enormously and developed many areas of subspecialty. The growth of important knowledge is well shown by the fact that the original 550 pages have been expanded to 900. The very same chapter topics have been used but they have been expanded and modernized, some of them very considerably. A few new chapters have been added in order to handle such interim developments as the uses of radioactivity and chromatography.
The 64 chapters are divided into 4 groups, as follows: Immunological and immunochemical methodology; applications and uses of quantitative immunochemical methods; chemical and
Ernest Witebsky. Experimental Immunochemistry. JAMA. 1962;179(7):584. doi:10.1001/jama.1962.03050070106026