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April 24, 1967

Successful, Normal Childbirth After Kidney Homotransplantation

Author Affiliations

From the departments of surgery/urology (Drs. Kaufman, Goodwin, and Martin), obstetrics and gynecology (Dr. Dignam), and medicine (Drs. Goldman and Maxwell), University of California School of Medicine, Los Angeles.

JAMA. 1967;200(4):338-341. doi:10.1001/jama.1967.03120170110031

IN APRIL, 1966 the first normal delivery at term after a kidney homotransplantation occurred at the Medical College of Virginia.1 On Sept 19, 1966, the second such event in this country occurred at the University of California, Los Angeles, Center for the Health Sciences. The similarity between the two cases is noteworthy. Both women had received a kidney homograft from a living relative a little more than a year earlier. Both patients maintained excellent renal function throughout pregnancy; both had normal vaginal deliveries at term, and in each case the newborn child appears to be entirely normal, despite maintenance of immunosuppressive therapy during pregnancy.

Report of a Case  A 35-year-old married woman (023-10-30) was admitted to the UCLA Hospital on June 18, 1965, for a possible kidney homotransplantation. In April 1964 her blood urea nitrogen was 60 mg/100 cc, and she required several transfusions for anemia. A diagnosis of