With the expanded use of antimalarial drugs based upon their effectiveness as anti-inflammatory agents, an increase in the number of adverse reactions to these agents was to be expected. This report describes the development of hepatitis and agranulocytosis in a patient who received amodiaquine, one of the newer antimalarials, and emphasizes the various reactions that may be encountered with these compounds. In the management of the patient presented, use of adrenocorticotropin and prednisone was considered lifesaving.
Perry HO, Bartholomew LG, Hanlon DG. Nearly Fatal Reaction to Amodiaquine. JAMA. 1962;179(8):598–601. doi:10.1001/jama.1962.03050080010003
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