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The increasing frequency of mycotic corneal ulcer is of considerable concern in present-day medicine. Of all the cases reported since the first one in 1879, more than half have occurred within the past 10 years. As new types of fungi are identified as the cause of corneal ulcer in almost every reported series, questions arise concerning the possible sources of these infecting organisms and the etiological factors involved. To properly define the problems presented, the first requisite is to cultivate these unfamiliar organisms from the lesions in order to identify them as to genus and species. A survey of presently known species isolated from corneal ulcers reveals the great majority to be saprophytic fungi which are "opportunistic." They will adapt to parasitic and pathogenic habitat under certain conditions.
The cornea normally is remarkably resistant to infection. It is not surprising, therefore, that some contributory cause is necessary for either well-known
FUNGAL CORNEAL ULCER. JAMA. 1962;179(8):649–650. doi:10.1001/jama.1962.03050080061014
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