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Negative Results
May 1, 1967

Corticosteroids and Croup: Controlled Double-Blind Study

Author Affiliations

From the Department of Pediatrics, Wyckoff Heights Hospital, Brooklyn, NY.

JAMA. 1967;200(5):403-404. doi:10.1001/jama.1967.03120180091014
Abstract

The value of corticosteroids in the treatment of acute croup remains in doubt. Support for their use comes primarily from the otolaryngology literature. Martensson, et al,1 Novik,2 and Davison3 maintain that the course of the illness is shortened by the antiinflammatory effect of steroid therapy. Morse4 stated that this form of treatment has reduced the incidence of tracheostomy. Leegaard5 does not agree with this concept. In a recent study, Eden and Larkin6 could not demonstrate any difference between the control and corticosteroidtreated groups.

In a further attempt to help resolve this question, a controlled, double-blind study was carried out on 50 hospital patients with acute croup.

Materials and Methods  Fifty consecutive patients admitted to the hospital with acute croup were included in this study. Children presenting with acute respiratory infections characterized by barking cough, hoarseness, sternal retractions, and respiratory stridor were included. One of

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