Despite the fact that statistical methods are being utilized more frequently in the practice of medicine, the author has not yet seen a biometric design which provides a realistic evaluation of supervoltage versus orthovoltage equipment in roentgenotherapy. Too many limiting factors (small series, differences in techniques, inability to randomize) are involved to permit accurate statistical appraisal. Comparison of supervoltage with orthovoltage therapy given preoperatively in the present series apparently showed that supervoltage gave the higher percentage of local cure in patients with lesions of the tonsillar bed, base of tongue, pharyngeal walls, cervix uteri, and breasts. Treatment of cancers originating in other anatomical sites is being investigated.
Fletcher GH. Problems in Clinical Evaluation of Radiotherapeutic Methods. JAMA. 1962;179(11):871–877. doi:10.1001/jama.1962.03050110039008
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