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March 17, 1962

NORMAL BLOOD PRESSURE IN COMPLETE RENAL DEPRIVATION

JAMA. 1962;179(11):893. doi:10.1001/jama.1962.03050110061016
Abstract

FOR many years it has been accepted that the kidney is intimately or remotely related to arterial hypertension. But the precise mechanism has been, and still is, a moot question. Animal experimentation has left much to be desired in answering this question. Some new light is cast on the subject by a recent report1 from the Peter Bent Brigham Hospital, Boston, on the observations of blood pressure responses of 4 patients who had been deprived of kidney tissue.

These patients, ranging in age from 11 to 31 years, were renoprival (without kidney tissue) for periods of time ranging from 10 to 62 days. Three of the patients had solitary pelvic kidneys, 2 of which were diseased, and 1 was injured; the 4th had subacute glomerulonephritis. During their renoprival state they all remained normotensive except when they became excessively hydrated. At that time there was a varying degree of pressure

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