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May 8, 1967

Seventh Multidiscipline Research Forum of the American Medical Association

JAMA. 1967;200(6):537-546. doi:10.1001/jama.1967.03120190163029

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1. The Use of Low Dosage Intermittent Methotrexate Therapy in the Production of Long-Term Remissions of Psoriatic Arthropathy

Jerome Botstein, MD, Rheumatic Disease Unit, Division of Medicine, Montefiore Hospital & Medical Center, and Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, New York

For one year, seven males and six females having psoriatic arthropathy uncontrolled by other drugs were given methotrexate. Methotrexate was administered orally in a dosage of 5 mg per day for 28 days. Thereafter the drug was discontinued for a similar period, and then treatment was reinstituted for 28 days. A remission of both the rash and arthritis was obtained in the first four weeks of therapy and was maintained during the period of four weeks in which methotrexate was not given. We have had two cases of transient leucopenia accompanied by mild diarrhea and stomatitis, both of which were rapidly reversed after discontinuing