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March 24, 1962

Local Subcutaneous Atrophy

JAMA. 1962;179(12):971-972. doi:10.1001/jama.1962.03050120000013d
Abstract

IN THE COURSE of evaluating the clinical effectiveness of a new long-acting parenteral form of triamcinolone, a peculiar local effect was observed. It is the purpose of this communication to describe the lesions produced and to discuss their possible significance.

The anti-inflammatory agent, triamcinolone diacetate, as a fine suspension of 40 mg. of active steroid per milliliter, was given intramuscularly or deeply subcutaneously in the upper arms, usually in doses of 40 mg. and sometimes of 20 mg. Injections were administered on a 3 to 14 day schedule to 27 patients with such allergic conditions as severe generalized atopic eczema or contact dermatitis, persistent asthma, or severe allergic rhinitis with obstructing polyps.

Onset of clinical relief varied between 24 and 48 hours, usually occurring 48 hours after injection. Duration of clinical effectiveness in these patients ranged between 4 and 12 days, in most instances being less than 7 days. Patients

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