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May 15, 1967

Eosinophilic Gastritis

Author Affiliations

From the departments of radiology, pathology and surgery of the Buffalo General Hospital, and the School of Medicine of the State University of New York at Buffalo.

JAMA. 1967;200(7):641-643. doi:10.1001/jama.1967.03120200119033

INFLAMMATORY CHANGES with eosinophilic infiltration of the walls of the gastrointestinal tract may occur in two forms. One is a circumscribed polypoid lesion, and the other consists of a diffuse infiltrative thickening of the walls. The former has been called in general eosinophilic granuloma,1-3 and in the specific case of the stomach has been described as inflammatory fibroid polyps4 and gastric fibroma with eosinophilic infiltration.5 This form is not usually associated with blood eosinophilia or an allergic history.

The diffuse type has been recorded in the literature under such names as eosinophilic granuloma,6 eosinophilic gastroduodenopathy,7 eosinophilic gastroenteritis,2,8 and in the specific case of the stomach as eosinophilic gastritis,9 gastric lesion of Loeffler's syndrome,10 eosinophilic linitis plastica,11 and gastric granuloma with eosinophilic infiltration.12 This type is commonly associated with blood eosinophilia and an allergic history.

Both forms have been described as