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May 15, 1967

The Genetics of Gastro-intestinal Disorders

JAMA. 1967;200(7):652. doi:10.1001/jama.1967.03120200130040

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This book will be welcomed by physicians interested in gastrointestinal functions and diseases and by geneticists working in clinical areas. The author points out that the gastrointestinal tract differs from other systems of the body in that there are very few gastrointestinal disorders whose pattern of heredity is obviously due to single genes of good penetrance and regular expression. More frequently, the inheritance appears to be polygenic. In these circumstances, the best one can do is to marshall all of the available evidence for the involvement of genetic factors in the etiology and to analyze it critically. This the author has done admirably.

However, this book is very much more than just an enumeration of the many family and twin studies on diseases of the digestive tract. In considering the various diseases on which genetic studies have been done, the author does not limit himself merely to listing the evidence