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In a family group of 199 members with a high incidence of hypertension, proved or probable pheochromocytomas have been demonstrated 8 times in 7 patients. In this kindred there also seemed to be an increased incidence of café-au-lait skin spots, hemangiomas, and angiomatosis retinae (Hippel's disease). The pheochromocytoma was associated with congenital cataracts in one of the patients and with renal artery stenosis in another.
Tisherman SE, Gregg FJ, Danowski TS. Familial Pheochromocytoma. JAMA. 1962;182(2):152–156. doi:10.1001/jama.1962.03050410048010
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