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May 22, 1967

Sarcoidosis During Pregnancy: Improvement in Pulmonary Function

Author Affiliations

From the Mayo Clinic, Rochester, Minn.

JAMA. 1967;200(8):726-727. doi:10.1001/jama.1967.03120210112027

THE MAJORITY of reports indicate little reciprocal effect, neither progression nor regression, of the sarcoidosis during pregnancy.1,2 Most authorities agree that the disease is benign and self-limited, and that about 90% of hilar and parenchymal lesions subside without treatment within one to two years.

We recently saw a young woman with pulmonary sarcoidosis who had complete roentgenographic regression of hilar adenopathy and improvement in pulmonary function during pregnancy. This case supports further, from a standpoint of pulmonary function, the concept that pregnancy may have a beneficial effect on sarcoidosis.

Report of a Case  A 24-year-old white schoolteacher and housewife was first examined at the Mayo Clinic on Feb 16, 1966. Red painful nodules characteristic of erythema nodosum had developed on both of her lower extremities in December 1965. During the subsequent two months she noticed exertional dyspnea and a sensation of being unable to take a deep breath. Physical