To the Editor:—
Dr. Harry Seneca has written an article entitled "Long-Acting Sulfonamides in Urinary Tract Infections" (198:975, 1966). I do not disagree with the content insofar as the sulfonamides are concerned.On page 979, Dr. Seneca states that nitrofurantoin does not give rise to biologically active tissue levels; yet the work we and others have published clearly demonstrates the presence of significant renal interstitial (renal lymph) concentrations of nitrofurantion.1-3 In fact, these interstitial concentrations exceed the corresponding blood levels. Our published data also clearly show that the renal lymph concentrations of nitrofurantoin are biologically active and suppress growth of Escherichia coli.Sweeping statements such as Dr. Seneca's run the danger of ignoring recent advances, leaving the reader with an erroneous conclusion.
Cockett ATK. Long-Acting Sulfonamides In Urinary Tract Infection. JAMA. 1967;200(9):799. doi:10.1001/jama.1967.03120220101034
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