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October 13, 1962

Orthostatic Hypotension Associated with Pernicious Anemia: Report of a Case with Complete Recovery Following Vitamin B12 Therapy

Author Affiliations

Oklahoma City

JAMA. 1962;182(2):198-200. doi:10.1001/jama.1962.03050410094021d

POSTURAL HYPOTENSION, first described by Bradbury and Eggleston in 1925, has been well documented in a variety of systemic diseases affecting the central nervous system such as tabes dorsalis and diabetes mellitus. The syndrome is characterized by orthostatic hypotension, a relatively fixed pulse rate (except with diabetes mellitus when it may be variable), and hypohidrosis. The following case report is of interest because it represents a well-documented case of orthostatic hypotension with pernicious anemia, and there was a complete remission following treatment with Cyanocobalamin (vitamin B12) and folic acid.

Report of a Case

A 66-year-old retired government employee was admitted to the Oklahoma City Veterans Administration Hospital in September, 1959, complaining of weakness and light-headed spells. His symptoms had begun 3 years previously but had subsided after several months of therapy which reputedly consisted of iron and liver. One year before admission, his symptoms had recurred, with associated anorexia, for