POSTURAL HYPOTENSION, first described by Bradbury and Eggleston in 1925, has been well documented in a variety of systemic diseases affecting the central nervous system such as tabes dorsalis and diabetes mellitus. The syndrome is characterized by orthostatic hypotension, a relatively fixed pulse rate (except with diabetes mellitus when it may be variable), and hypohidrosis. The following case report is of interest because it represents a well-documented case of orthostatic hypotension with pernicious anemia, and there was a complete remission following treatment with Cyanocobalamin (vitamin B12) and folic acid.
Report of a Case
A 66-year-old retired government employee was admitted to the Oklahoma City Veterans Administration Hospital in September, 1959, complaining of weakness and light-headed spells. His symptoms had begun 3 years previously but had subsided after several months of therapy which reputedly consisted of iron and liver. One year before admission, his symptoms had recurred, with associated anorexia, for
Kalbfleisch JM, Woods AH. Orthostatic Hypotension Associated with Pernicious Anemia: Report of a Case with Complete Recovery Following Vitamin B12 Therapy. JAMA. 1962;182(2):198–200. doi:10.1001/jama.1962.03050410094021d
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