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June 5, 1967

Vaccination of Infants Against Influenza With Polyvalent Influenza Hemagglutinin

Author Affiliations

From the Department of Epidemiology and the Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor.

JAMA. 1967;200(10):896-898. doi:10.1001/jama.1967.03120230148033

LITTLE information is available on the amount of antigen and the number of doses necessary to induce antibody levels in young infants receiving influenza virus vaccine. The reason is that the very high frequency and severity of reactions to potent whole virus vaccines in infants and young children has restricted their use in these age groups.1

However, it has been demonstrated that as much as 500 chick-cell agglutination (CCA) units of influenza hemagglutinin vaccine, prepared by extraction of virus with ether followed by precipitation of nucleoprotein with lanthanum acetate, can be given to older infants (1 to 2 years old) and preschool children without induction of fever. Furthermore, hemagglutinin vaccine is highly antigenic in children and adults.2,3

In light of this, a study was initiated on the antibody response and tolerance of young infants to graded doses of polyvalent influenza hemagglutinin vaccine. The results constitute the body of