Five hundred patients were treated with intensive parenteral and local administration of antibiotics and with maximum exposure. Analysis of the mortality among this group of patients was performed by the probit method. Comparison of this mortality with that obtained at burn centers that used other methods of treatment suggests that intensive prophylactic antibiotic therapy may have merit in the treatment of severe burns.
Collentine GE, Waisbren BA, Mellender JW. Treatment of Burns With Intensive Antibiotic Therapy and Exposure. JAMA. 1967;200(11):939–942. doi:10.1001/jama.1967.03120240067010
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