Furosemide is a potent, orally effective diuretic with a prompt onset and short duration of action. It is of particular use in the treatment of refractory edema in patients who do not respond to or cannot tolerate the older diuretics. Most adverse effects associated with the use of furosemide are relatively mild, and generally resemble those of the thiazides, but the dosage must be carefully individualized to avoid excessive diuresis. To minimize the danger of dehydration and electrolyte imbalance, it is usually best to use intermittent therapy.
Evaluation of a New Oral Diuretic Agent: Furosemide (Lasix). JAMA. 1967;200(11):979–980. doi:10.1001/jama.1967.03120240107021
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