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June 19, 1967

Immunology in Ulcerative Colitis

Author Affiliations

Oakland, Calif

JAMA. 1967;200(12):1133. doi:10.1001/jama.1967.03120250167030

To the Editor:—  Because the editorial "The Immunological Aspects of Ulcerative Colitis" (198:659, 1966) failed to mention atopic allergy to food and pollens, we believe that the following comments deserve consideration.Food allergy as a cause of chronic ulcerative colitis (CUC) was first reported by Andresen in 1933,1 and has been reported by us since 1942.3 Pollen allergy as a sole etiological factor, or associated with food allergy, was also reported by us in 1942 and reemphasized in 1955.3 We are convinced that when the causative food or pollen allergy is controlled by increasing numbers of physicians, atopic allergy will be recognized as a major cause of CUC.The causative role of atopic allergy was given support with the demonstration of gamma globulin antibodies to milk by Trueblood and Wright in 1961.4 Although these antibodies are found in clinically non-milk-sensitive individuals, they occur more often