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October 20, 1962

Genetic Factors in Intestinal Polyposis

Author Affiliations

From the Division of Medical Genetics, Department of Medicine, Johns Hopkins Hospital and Johns Hopkins University School of Medicine.

JAMA. 1962;182(3):271-277. doi:10.1001/jama.1962.03050420047012

At least 6 distinct varieties of hereditary polyposis of the gastrointestinal tract can be identified. The clinical and genetic characteristics are different. In 3 of the 6, the occurrence of extra-alimentary manifestations aids diagnosis. Intestinal polyposis illustrates the usefulness of genetic understanding in the practice of preventive medicine in families.