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October 20, 1962

Treatment of Malignant Melanoma of the Orbit with Intra-Arterial Methotrexate

Author Affiliations


JAMA. 1962;182(3):300-301. doi:10.1001/jama.1962.03050420076022b

REGIONAL PERFUSION and infusion is developing into an increasingly important technique in the treatment of malignant tumors.

Creech et al. and other investigators have reported on the treatment of malignant melanoma and other malignant tumors of an extremity by regional perfusion with the alkylating agents.

Sullivan et al. reported in 1959 on the treatment of epithelial tumors of the head and neck by the continuous infusion of very large doses of an antimetabolite—methotrexate (4-amino-N-methyl-pteroylglutamic acid)—through the external carotid artery. Citrovorum factor (the antidote to methotrexate) was administered intermittently during this procedure by the intramuscular route to neutralize, to some degree, systemic toxicity. Subsequently these authors also reported the treatment of cancer of the cervix and of the brain by the same method. The results of these procedures were encouraging and resulted in some remissions lasting many months. Prior to our case, the above technique had never been used in the