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Article
October 20, 1962

Tetanus Antitoxin Skin Tests

Author Affiliations

950 Park Ave., New York City 28

JAMA. 1962;182(3):315. doi:10.1001/jama.1962.03050420091029

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Abstract

To the Editor:—  The report by Dr. Eade, entitled "The Unreliability of Tetanus Antitoxin Skin Tests After Injury" (JAMA180:972 [June 16] 1962), emphasizes that after severe trauma the reduced skin blood flow may be sufficient to produce a false negative, intradermal reaction to tetanus antitoxin (TAT). He states that "the usual practice after injury is to give a skin test, observe for 20 to 30 minutes, and then give TAT." Correct practice consists of obtaining a complete history of allergic conditions, especially sensitivity to horse dander or serum, and testing with normal horse serum by both the intradermal and conjunctival methods. A positive conjunctival reaction, although rarer than a positive intradermal reaction, is much more significant, and is a contraindication to administering the serum. The exact technique for performing these tests and the procedure for administration of TAT, based on the results of the history and the testing,

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