The isolated human auricular myocardium has been shown to be an excellent system for in vitro drug testing. This tissue will beat spontaneously and will respond to epinephrine in classical fashion with an increase in both the force and the rate of contraction. When the adrenergic blocking drug, dichloroisoproterenol, was tested, it was found to block these effects of epinephrine, supporting the reliability of this test system.
Rosenblum I, Si AA, Kausel H. I. Pharmacod Isolated Human: nic Studies on cular Myocardium. JAMA. 1962;182(5):532–534. doi:10.1001/jama.1962.03050440024007
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