[Skip to Content]
[Skip to Content Landing]
November 3, 1962

I. Pharmacod Isolated Human: nic Studies on cular Myocardium

Author Affiliations

Albany, N.Y.
The 3 parts of this communication are from the departments of pathology (Drs. Stein and Chang and Mr. Thibodeau), pharmacology (Dr. Rosenblum), and surgery (Drs. Kausel, Stranahan, and Alley), the Albany Medical College of Union University.

JAMA. 1962;182(5):532-534. doi:10.1001/jama.1962.03050440024007

The isolated human auricular myocardium has been shown to be an excellent system for in vitro drug testing. This tissue will beat spontaneously and will respond to epinephrine in classical fashion with an increase in both the force and the rate of contraction. When the adrenergic blocking drug, dichloroisoproterenol, was tested, it was found to block these effects of epinephrine, supporting the reliability of this test system.