John L. Sever, M.D., Ph.D., Gilbert M. Schiff, M.D., and Renee G. Traub, B.A., Bethesda, Md.WHILE THE VIRAL ETIOLOGY of rubella is generally accepted, the isolation and cultivation of the virus have not been established conclusively. Studies conducted by Hiro and Tasaka1 in 1938 and confirmed by Anderson2 in 1949 revealed that rubella could be produced in susceptible children who were inoculated with filtered nasal washings from acute cases of rubella. Krugman et al.3 in 1953 extended this information by showing that blood taken 2 days before the rash or on the day of the rash caused rubella in susceptible humans. They also established that rubella could occur without a rash. Gutekunst and Heggie4 in 1961 proposed that some cases of rubella among military recruits might be associated with adenovirus Type 4 or 7 infection. Habel5 in 1942 reported having transmitted the
Clinical Science. JAMA. 1962;182(6):663–671. doi:10.1001/jama.1962.03050450063013
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