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November 10, 1962

Histoplasmosis with Massive Pericardial Effusion and Systemic Involvement: Report of a Case

Author Affiliations

Akron, Ohio

JAMA. 1962;182(6):687-689. doi:10.1001/jama.1962.03050450087020d

IN INCBEASING NUMBEB of cases of histoplasmosis have been reported since Hansmann, Schenken, and DeMonbreun cultured Histoplasma capsulatum from cases in 1934. The course, manifestations, organ involvement, epidemiological aspects, endemic, and worldwide distribution of this protean disease are well documented.

Heart involvement has been reported with increasing frequency. The etiological agent affects all 3 layers: endocardium, myocardium, and the pericardium. The cases of pericarditis were diagnosed mainly on a sensitivity basis and were manifested as chronic, healed, calcific pericarditis. One case of constrictive pericarditis was added to this category. In addition, a case of an acute form of pericarditis with massive effusion due to histoplasmosis was recently reported. The authors were unable to substantiate any other cases in the literature with special localization in and involvement of the pericardium. The case being reported here coincided with the time their case was published, and we believe that the following may be of