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July 3, 1967

Brain Tumor Chemotherapy With Methotrexate Given Intrathecally: A New Technique

Author Affiliations

From the Department of Surgery, Division of Neurosurgery, University of Kentucky School of Medicine, Lexington.

JAMA. 1967;201(1):15-17. doi:10.1001/jama.1967.03130010041009

A new technique has been described for the intrathecal administration of cytotoxic agents with use of the components of a ventriculoatrial shunt. The results obtained in six patients given methotrexate intrathecally for a variety of intracranial tumors justifies further clinical trial.