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January 19, 1963

An introduction to diagnostic enzymology.

Author Affiliations

Winston-Salem, N.C.

JAMA. 1963;183(3):224. doi:10.1001/jama.1963.03700030100032

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The ever increasing use of enzyme determinations as aids to clinical diagnosis has led to the accumulation of a large number of results of widely different value and significance. The stated purposes of Wilkinson's book are to critically review the available information and to offer to the clinician a guide in choosing those determinations which, in the present status of our knowledge, seem to be most appropriate to a given clinical condition. In the reviewer's opinion, these aims have been quite successfully attained. The general concepts of the structure, mode of action, terminology, and classification of enzymes are first presented in clear, concise language. Next, the author briefly outlines the mechanisms through which changes in the enzymatic activities of body fluids occur in disease, and points out how and to what extent such changes may supply useful diagnostic information. Further considerations and some plausible speculations concerning the source, mechanisms of

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