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July 24, 1967

The Lymphocytes

JAMA. 1967;201(4):277. doi:10.1001/jama.1967.03130040073036

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Today's practitioner of medicine and biomedical investigator must strive to see the forest as well as the trees. For the subject of lymphocytes, this goal is placed within easier reach by this monograph. The author has critically analyzed an impressive body of specific observations and their interpretations, to which he himself has made significant contributions, and synthesized them into a meaningful composite of the physiopathology of lymphocytes. A concise outline of morphologic and biochemical aspects of lymphocytes includes cytochemical and electron microscopic features of their ultrastructure. This is followed by discussion of formation, life span, and recirculation of the cells.

As indicated by the plural in the title, Elves considers the small lymphocytes, as found in blood and tissues, to be "a heterogeneous collection of cells." A strong case is presented for a sizable population of lymphocytes with a long life span, during which they frequently pass from blood to