This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Inflammatoryrcinoma of the breast is a clinical entity with no distinct histologic characteristics. The term is derived from the fact that the involved breast shows the cardinal signs and symptoms of inflammation—redness, heat, swelling, and pain. The condition was first described by Lee and Tannenbaum32 in 1924 and later emphasized by Taylor and Meltzer33 in 1938 as an uncommon variant of breast cancer. Haagensen's31 diagnostic criteria are enlargement of the breast, either a distinct breast mass or generalized induration, redness and edema of the mammary skin, and biopsy proof of carcinoma; the redness must involve more than one third of the breast.
This type of carcinoma is usually extremely undifferentiated with high-grade malignancy. There is extensive involvement and blockage of the dermal and subdermal lymphatics, resulting in edematous thickening and reddening of the skin, a characteristic pitted appearance known as "peau d'orange" or "pigskin."
The disease is
Wang C. Management of Inflammatory Carcinoma of the Breast. JAMA. 1967;201(7):533. doi:10.1001/jama.1967.03130070053016
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: