[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Sept 4, 1967

Cytomegalovirus Infection After Renal Allotransplantation

Author Affiliations

From the departments of pathology (Dr. Craighead) and medicine (Dr. Carpenter), Peter Bent Brigham Hospital and Harvard Medical School, Boston; and the Department of Pediatrics, University of Rochester (NY) School of Medicine and Dentistry, Rochester (Dr. Hanshaw).

JAMA. 1967;201(10):725-728. doi:10.1001/jama.1967.03130100023007

Cytomegalovirus (CMV) infection was established by virologic or serologic studies or both in 30 of 41 renal allograft recipients (73%) who survived one or more months after transplantation. The infection occurred in 22 of the 24 patients (91%) with serologic evidence of exposure to CMV before transplantation, but in only eight of 17 (47%) who had no demonstrable serum antibody at the time of the surgical procedure. The data strongly suggest that active CMV infection in renal graft recipients can result either from the activation of "latent" virus or from exposure to the virus after transplantation. The occurrence of the infection did not correlate with a well-defined clinical syndrome even though generalized cytomegalic inclusion disease was found in some patients at autopsy.