[Skip to Content]
[Skip to Content Landing]
Sept 18, 1967

Preexposure Prophylaxis Against Rabies: Comparison of Regimens

Author Affiliations

From the Rabies Control Unit, Veterinary Public Health Section, Epidemiology Program, National Communicable Disease Center, Atlanta. Dr. Tierkel is now with the Agency for International Development.

JAMA. 1967;201(12):911-914. doi:10.1001/jama.1967.03130120019005

During investigations to determine a satisfactory, practical preexposure regimen for administering rabies vaccine to groups of people at high risk, a total of 540 volunteers received vaccine of chick or duck embryo origin. The results of these studies indicate that the most practical regimen consists of two subcutaneous injections of 1.0 ml of duck embryo rabies vaccine given a month apart followed by a booster of 1.0 ml of the vaccine seven months after the second injection. Ninety percent of the volunteers who were on this regimen had a detectable serum neutralizing antibody titer one month after the last injection.