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Sept 18, 1967

Comparison of Two Dosages of Ragweed Extract in the Treatment of Pollenosis

Author Affiliations

From the departments of medicine, Harvard Medical School and the Massachusetts General Hospital, Allergy Unit, Boston.

JAMA. 1967;201(12):915-917. doi:10.1001/jama.1967.03130120023006

A double-blind study was carried out to determine the effect of dosage in the treatment of ragweed hay fever with injections of aqueous ragweed pollen extract. Two concentrations of extract were used, one 20-fold smaller than the other. The volumes administered were such that the dose at the higher concentration was close to the maximum that it is practical to administer. During the ragweed season, the group of patients receiving the higher concentration fared significantly better than the group receiving the lower concentration. It is concluded that large dosages of pollen extract are more effective than small dosages in the treatment of hay fever. The findings indicate that the very low dosages recommended by some would have little influence on the course of pollenosis.