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Sept 18, 1967

Subnormal Levels of Glucose in UrineA Sign of Urinary Tract Infection

Author Affiliations

From the departments of clinical chemistry (Dr. Scherstén) and medical microbiology (Dr. Fritz), University Hospital, Lund, Sweden.

JAMA. 1967;201(12):949-952. doi:10.1001/jama.1967.03130120057014

Since the middle of the 19th century, it has been known that normal urine contains small quantities of glucose.1-3 Nevertheless, the present knowledge concerning the physiological range of urinary glucose concentrations is on the basis of only a few reports. Nagasaki4 found the normal range to be 2 to 33 mg of glucose per 100 milliliters of urine in a study of 174 randomly selected cases. In specimens of morning urine Haller5 recorded values from less than 3.1 to 12.5 mg/100 ml of urine in a small series. Using a glucose oxidase method, Fine6 found the normal range in 740 individuals to be 1 to 15 mg/100 ml of urine. In his studies the urinary specimens were not collected in the fasting state.

Renschler7 used the hexokinase glucose-6-phosphate dehydrogenase method in an extensive study of urinary glucose in 159 individuals. He found the upper limit