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Sept 18, 1967

Subnormal Levels of Glucose in Urine: A Sign of Urinary Tract Infection

Author Affiliations

From the departments of clinical chemistry (Dr. Scherstén) and medical microbiology (Dr. Fritz), University Hospital, Lund, Sweden.

JAMA. 1967;201(12):949-952. doi:10.1001/jama.1967.03130120057014

Since the middle of the 19th century, it has been known that normal urine contains small quantities of glucose.1-3 Nevertheless, the present knowledge concerning the physiological range of urinary glucose concentrations is on the basis of only a few reports. Nagasaki4 found the normal range to be 2 to 33 mg of glucose per 100 milliliters of urine in a study of 174 randomly selected cases. In specimens of morning urine Haller5 recorded values from less than 3.1 to 12.5 mg/100 ml of urine in a small series. Using a glucose oxidase method, Fine6 found the normal range in 740 individuals to be 1 to 15 mg/100 ml of urine. In his studies the urinary specimens were not collected in the fasting state.

Renschler7 used the hexokinase glucose-6-phosphate dehydrogenase method in an extensive study of urinary glucose in 159 individuals. He found the upper limit