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Article
Sept 18, 1967

Management of Narcotic-Drug Dependence by High-Dosage Methadone HC1 Technique: Dole-Nyswander Program

JAMA. 1967;201(12):956-957. doi:10.1001/jama.1967.03130120064016
Abstract

The record of treatment of narcotic-drug-dependent persons is often considered to be a disappointing one. It is no surprise, therefore, that physicians and laymen alike are impressed when a management method emanating from a recognized medical institution is given wide newspaper and magazine publicity as a successful procedure.

Vincent P. Dole, Jr., MD, and Marie E. Nyswander, MD, originated the high-dosage methadone hydrochloride technique to maintain the heroin abuser in a tolerant and drug-dependent state. Their preliminary report, which appeared in The Journal,1 gave hope to many physicians that a more effective treatment was in the offing. It is disquieting to those who would like to see this program continue at a properly controlled research level to know that it has since been presented as if it were an established effective treatment method that might be taught to any interested physician.

An advisory committee to the US Commissioner of

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