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Sept 25, 1967

Prevention of Renal Necrosis by Stress

Author Affiliations

From the Institut de Medicine et de Chirurgie expérimentales, Université de Montréal, Canada.

JAMA. 1967;201(13):1026-1029. doi:10.1001/jama.1967.03130130052013

By obstructing the renal hilus for two hours with a specially constructed clip, it is possible to produce a selective necrosis affecting the medulla of the rat kidney. Despite total cessation of urine secretion, the cortex, though altered in its structure, continues to live for many weeks without producing hypertension, generalized periarteritis nodosa, or nephrosclerosis on the opposite side. In these respects as well as in its histologic structure, this "cortical kidney" differs essentially from the "endocrine kidney" elicited by permanent but partial restriction of the renal blood flow. Exposure to systemic stress (restraint, spinal-cord transection) and treatment with certain drugs (chlorpromazine hydrochloride, cyproheptadine hydrochloride) offer virtually complete protection against the macroscopic and histologic manifestations of the ischemic renal necrosis thus produced.