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Sept 25, 1967


JAMA. 1967;201(13):1040-1041. doi:10.1001/jama.1967.03130130066017

Research,like therapeutics, experiences cyclic fads. These are characterized by a rush of investigators towards an avenue of research initiated by publication of a few promising studies. For nearly fifteen years, an almost embarrassingly high number of researchers boarded the "cholesterol bandwagon" in pursuit of understanding of atherosclerosis. This fervent embrace of cholesterol to the exclusion of other biochemical alterations resulted in a narrow scope of study of a disease which is probably multifaceted in causation. Fortunately, other fruitful approaches have been made possible in the past few years by identification of the fundamental role of such factors as triglycerides and carbohydrate metabolism in atherogenesis.

Recognition that study of atherosclerotic subjects should include evaluation of carbohydrate metabolism was prompted by epidemiologic analyses, which demonstrated high levels of blood glucose with significant frequency among persons with atherosclerosis. The interrelationships between carbohydrate and lipid metabolism have been the subject of more recent investigations.