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Sept 25, 1967

Convulsions Following Intrapleural Administration of Quinacrine Hydrochloride

Author Affiliations

From the divisions of clinical pharmacology and oncology, Medical Service, Lemuel Shattuck Hospital, and Tufts University School of Medicine, Boston.

JAMA. 1967;201(13):1049-1050. doi:10.1001/jama.1967.03130130075023

Convulsions developed in two patients after intrapleural administration of quinacrine hydrochloride for malignant effusions. Status epilepticus, resulting in death, occurred in one patient. A possible causal relationship may have been accentuated by corticosteroid therapy.