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Article
Sept 25, 1967

Cyanoacrylate Tissue Adhesives

JAMA. 1967;201(13):1052-1053. doi:10.1001/jama.1967.03130130078029
Abstract

To the Editor:—  The editorial "Cyanoacrylate Tissue Adhesives" (201:195, 1967) deserves comment. Experimental observations1,2 have demonstrated a dichotomy among the alkyl-2-cyanoacrylates in regard to local toxicity. The methyl and ethyl esters are locally toxic, but the higher homologues, such as n-butyl, n-pentyl, n-hexyl, and n-decyl are not. We did not report1 that "as one proceeds up the homologous series, histotoxicity decreases," but rather showed that the methyl homologue was logically toxic whereas the hexyl and decyl homologues were not. The latter two materials evoked similar responses.In regard to rates of polymerization, these rates can be varied for any monomer. They are directly related to purity of the monomer, surface area exposed to catalysis, and effective catalyst concentration and are inversely related to the local concentration of acidic inhibitor substances. These factors, especially purity of the monomer, control polymerization time. Thus factors other than rate of polymerization

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