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October 2, 1967

Transaminase Levels in the Postconvalescent Phase of Infectious Hepatitis

Author Affiliations

From the Hepatitis Unit (Dr. Reisler) and Viral Disease Section (Dr. Mosley), Epidemiology Program, and the Hepatitis Activities, Laboratory Program (Dr. Strong), National Communicable Disease Center, Public Health Service, US Dept of Health, Education, and Welfare, Atlanta. Dr. Reisler is now at Barnes Hospital, St. Louis, and Dr. Strong at the Cleveland Metropolitan General Hospital, Cleveland.

JAMA. 1967;202(1):37-41. doi:10.1001/jama.1967.03130140095015

Forty-one persons, mostly children, were followed up with serial serum glutamic pyruvic transaminase (SGPT) determinations for 6 to 12 months after onset of acute infectious hepatitis. An abnormal level was observed in the postconvalescent period in 12 (29%) of these. Most children with SGPT abnormality were asymptomatic; among the few with mild residual complaints, there appeared to be no necessary correlation with SGPT level. Observations made approximately one year after onset did not suggest that chronic hepatitis had developed within that interval in any of the children. It does not appear that SGPT abnormality is a reason by itself for reinstituting bed rest or restricting activity.